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  3. Developmental Origins of Health and Disease
  • Cited by 6
Publisher:
Cambridge University Press
Online publication date:
December 2022
Print publication year:
2022
Online ISBN:
9781009272254
DOI:
https://doi.org/10.1017/9781009272254
Subjects:
Obstetrics and Gynecology, Reproductive Medicine, Medicine, Pediatrics and Child Health
Information

Book description

The concept of the early life developmental origins of health and disease (DOHaD) in adults has stimulated a new approach to understanding disease trajectories, with major public health implications. Indeed, the principle of the 'lifecourse of disease' now influences health policies internationally. Environmental influences during pregnancy and early life that affect lifelong health are well documented, but there is a new focus on the preconception period and the significance of paternal health on the fetus. This fully revised second edition highlights scientific and clinical advances in the field, exploring new understanding of mechanisms such as epigenetics and the increasingly recognised role of external influences, including pollution. The book is structured logically, covering environment, clinical outcomes, mechanisms of DOHaD, interventions throughout the lifespan and finally implications for public health and policy. Clinicians and scientists alike will improve their understanding of the developmental origins of health and disease with this essential text.

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