This chapter seeks to evaluate the potentiality that Deleuze offers to our understandings of sexuality and disability. Such an encounter is at the heart of what we might term critical disability studies where disability links together other identities, politics and cultural agitations as a moment of reflection for which Davis coins the term ‘dismodernism’ (Davis 2006). With specific reference to sexuality and the concepts of Deleuze and Guattari1 – and in particular to the ideas of the Deleuzian disability theorist Margrit Shildrick – we will here take up the dismodernist challenge in our applied social scientific research in order to think affirmatively and politically about the intersections of disability and sexuality. First, we will consider the ways in which critical disability studies have recently started to engage with a Deleuzian perspective in order to theorise an affirmative view of disability.