Status epilepticus is classified into generalized convulsive status epilepticus (GCSE) and non-convulsive status epilepticus. This chapter discusses the aetiology of status epilepticus and pathophysiology of GCSE. It lists out different drugs such as benzodiazepines, diazepam, lorazepam, midazolam, phenytoin, fosphenytoin, phenobarbitone, thiopentone and popofol for terminating seizure activity. Refractory status epilepticus patients require intubation and ventilation and possibly pressor support in a critical care setting. Long-term and maintenance anti-epileptic drug (AED) therapy must be given in tandem with emergency treatment. The prognosis of patients with status epilepticus is related to the aetiology, age, duration of seizures and prompt initiation of treatment. Young patients whose status epilepticus was caused by low AED levels or systemic infection have very low mortality. In contrast, status epilepticus caused by cerebrovascular accident in the elderly has mortality of 35% and that associated with anoxic injury is usually fatal.