Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-26T15:12:49.081Z Has data issue: false hasContentIssue false

Chapter 19 - Opportunistic Salpingectomy in Transgender and Gender Diverse People

from Section C - Gynecological Surgery for Transgender Males

Published online by Cambridge University Press:  22 December 2022

By
Jurgen M.J. Piek  and
Joanne A. de Hullu
Edited by
Mick van Trotsenburg ,
Rixt A. C. Luikenaar  and
Maria Cristina Meriggiola
Mick van Trotsenburg
Affiliation:
Sigmund Freud PrivatUniversität, Wien
Rixt A. C. Luikenaar
Affiliation:
Rebirth Health Center, Utah
Maria Cristina Meriggiola
Affiliation:
Università di Bologna
Get access

Summary

Despite aggressive treatment, ovarian cancer has a poor prognosis. Therefore, there is an urgent need for primary prevention. Recently, the Fallopian tube has been indicated as organ of origin of most epithelial ovarian cancers. Therefore, an additional (opportunistic) salpingectomy during intraabdominal procedures will lower the burden on epithelial ovarian cancer. The pros and cons of an opportunistic salpingectomy should routinely be discussed also with trans male persons having left the Fallopian tubes in situ and undergoing abdominal surgery for any reason.

Type
Chapter
Information
Context, Principles and Practice of TransGynecology
Managing Transgender Patients in ObGyn Practice
 , pp. 145 - 147
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Torre, LA, Trabert, B, DeSantis, CE, et al. Ovarian cancer statistics, 2018. CA Cancer J Clin 2018;68(4):284–296. https://doi.org/10.3322/caac.21456Google Scholar
Lheureux, S, Gourley, C, Vergote, I, Oza, AM. Epithelial ovarian cancer. Lancet 2019;393(10177):1240–1253. https://doi.org/10.1016/S0140-6736(18)32552-2Google Scholar
Menon, U, Karpinskyj, C, Gentry-Maharaj, A. Ovarian cancer prevention and screening. Obstet Gynecol 2018;131(5):909–927. https://doi.org/10.1097/AOG.0000000000002580CrossRefGoogle ScholarPubMed
Fathalla, MF. Ovarian cancer of tubal origin, incessant ovulation and implications for clinical practice. Am J Clin Exp Obs Gynecol 2015;2(3):130–135.Google Scholar
Piek, JMM, van Diest, PJJ, Zweemer, RPP, Kenemans, P, Verheijen, RHH. Tubal ligation and risk of ovarian cancer. Lancet 2001;358(9284):844. https://doi.org/10.1016/S0140-6736(01)05992-XGoogle Scholar
Soong, TR, Howitt, BE, Horowitz, N, Nucci, MR, Crum, CP. The fallopian tube, “precursor escape” and narrowing the knowledge gap to the origins of high-grade serous carcinoma. Gynecol Oncol 2019;152(2):426–433. https://doi.org/10.1016/j.ygyno.2018.11.033CrossRefGoogle Scholar
Piek, JMJ, Kenemans, P, Verheijen, RHM. Intraperitoneal serous adenocarcinoma: a critical appraisal of three hypotheses on its cause. Am J Obstet Gynecol 2004;191(3):718–732. https://doi.org/10.1016/j.ajog.2004.02.067Google Scholar
Crum, CP, McKeon, FD, Xian, W. The oviduct and ovarian cancer: causality, clinical implications, and “targeted prevention.” Clin Obstet Gynecol 2012;55(1):24–35. https://doi.org/10.1097/GRF.0b013e31824b1725CrossRefGoogle ScholarPubMed
Piek, JMJ. From paradigm shift towards ovarian cancer prevention. BJOG An Int J Obstet Gynaecol 2017;124(2):314–320. https://doi.org/10.1111/1471-0528.14278Google Scholar
Piek, JMJMJ, Verheijen, RHMHM, Menko, FHH, et al. Expression of differentiation and proliferation related proteins in epithelium of prophylactically removed ovaries from women with a hereditary female adnexal cancer predisposition. Histopathology 2003;43(1):26–32. https://doi.org/10.1046/j.1365-2559.2003.01654.xGoogle Scholar
Soong, TR, Howitt, BE, Miron, A, et al. Evidence for lineage continuity between early serous proliferations (ESPs) in the Fallopian tube and disseminated high-grade serous carcinomas. J Pathol 2018;246(3):344–351. https://doi.org/10.1002/path.5145CrossRefGoogle ScholarPubMed
Kuhn, E, Kurman, RJ, Vang, R, et al. TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma-evidence supporting the clonal relationship of the two lesions. J Pathol 2012;226(3):421–426. https://doi.org/10.1002/path.3023Google Scholar
Labidi-Galy, SI, Papp, E, Hallberg, D, et al. High grade serous ovarian carcinomas originate in the fallopian tube. Nat Commun 2017;8(1):1093. https://doi.org/10.1038/s41467-017-00962-1CrossRefGoogle ScholarPubMed
Ducie, J, Dao, F, Considine, M, et al. Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma. Nat Commun 2017;8(1):990. https://doi.org/10.1038/s41467-017-01217-9Google Scholar
Eckert, MA, Pan, S, Hernandez, KM, et al. Genomics of ovarian cancer progression reveals diverse metastatic trajectories including intraepithelial metastasis to the fallopian tube. Cancer Discov 2016;6(12):1342–1351. https://doi.org/10.1158/2159-8290.CD-16-0607CrossRefGoogle Scholar
Madsen, C, Baandrup, L, Dehlendorff, C, Kjaer, SK. Tubal ligation and salpingectomy and the risk of epithelial ovarian cancer and borderline ovarian tumors: a nationwide case-control study. Acta Obstet Gynecol Scand 2015;94(1):86–94. https://doi.org/10.1111/aogs.12516Google Scholar
Falconer, H, Yin, L, Gronberg, H, Altman, D. Ovarian cancer risk after salpingectomy: a nationwide population-based study. JNCI J Natl Cancer Inst 2015;107(2):dju410-dju410. https://doi.org/10.1093/jnci/dju410Google Scholar
Vermeulen, RFM, Beurden, M van, Korse, CM, Kenter, GG. Impact of risk-reducing salpingo-oophorectomy in premenopausal women. Climacteric 2017;20(3):212–221. https://doi.org/10.1080/13697137.2017.1285879CrossRefGoogle ScholarPubMed
Madalinska, JB, Van Beurden, M, Bleiker, EMA, et al. The impact of hormone replacement therapy on menopausal symptoms in younger high-risk women after prophylactic salpingo-oophorectomy. J Clin Oncol 2006;24(22):3576–3582. https://doi.org/10.1200/JCO.2005.05.1896Google Scholar
van Lieshout, LAM, Steenbeek, MP, De Hullu, JA, et al. Hysterectomy with salpingectomy versus hysterectomy alone. Cochrane Database Syst Rev 2017;2017(11):CD012858. https://doi.org/10.1002/14651858.CD012858Google Scholar
Hehenkamp, WJK, Volkers, N, Broekmans, FJM, et al. Loss of ovarian reserve after uterine artery embolization: a randomized comparison with hysterectomy. Hum Reprod 2007;22(7):1996–2005. https://doi.org/10.1093/humrep/dem105CrossRefGoogle ScholarPubMed
Choi, HG, Jung, YJ, Lee, SW. Increased risk of osteoporosis with hysterectomy: a longitudinal follow-up study using a national sample cohort. Am J Obstet Gynecol 2019;220(6):573.e1–573.e13. https://doi.org/10.1016/j.ajog.2019.02.018Google Scholar
Laughlin-Tommaso, SK, Khan, Z, Weaver, AL, et al. Cardiovascular and metabolic morbidity after hysterectomy with ovarian conservation: a cohort study. Menopause 2018;25(5):483–492. https://doi.org/10.1097/GME.0000000000001043Google Scholar
Steenbeek, MP, van Lieshout, LAM, Aarts, JWM, et al. Factors influencing decision-making around opportunistic salpingectomy: a nationwide survey. J Gynecol Oncol 2019;30(1):e2. https://doi.org/10.3802/jgo.2019.30.e2Google Scholar
van Lieshout, LAM, Gelderblom, ME,, de Hullu, JA, et al. Primary prevention of ovarian cancer: a patient decision aid for opportunistic salpingectomy. AJOG 2022;226(2):234 E1–234 E14CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×