By the eighteenth century, North America thrived on its global commercial connections. For colonists like Benjamin Fuller, a Philadelphia dealer, and Thomas Nightingale, a South Carolina trader, these connections were the engine of their working lives. Over the middle of the eighteenth century, both men constructed complex business networks as they made their way by buying and selling a huge variety of commodities with an equally eclectic variety of people. Their complicated networks were the matter of which early American commercial connectivity was constituted, and they illustrate how Americans’ trading worlds were a complex combination of overseas, hemispheric, and continental ties.