Book contents
- Frontmatter
- Contents
- List of Contributors
- Preface
- NEURODEVELOPMENTAL MECHANISMS IN PSYCHOPATHOLOGY
- Part One Basic Mechanisms in Prenatal, Perinatal, and Postnatal Neurodevelopmental Processes and Their Associations with High-Risk Conditions and Adult Mental Disorders
- Part Two Animal Models of Neurodevelopment and Psychopathology
- Part Three Models of the Nature of Genetic and Environmental Influences on the Developmental Course of Psychopathology
- Part Four The Neurodevelopmental Course of Illustrative High-Risk Conditions and Mental Disorders
- 17 Neurobiology of Personality Disorders: Implications for a Neurodevelopmental Model
- 18 Genesis and Epigenesis of Psychopathology in Children with Depressed Mothers: Toward an Integrative Biopsychosocial Perspective
- 19 The Neurobiology of Child and Adolescent Depression: Current Knowledge and Future Directions
- 20 Psychosocial Stressors as Predisposing Factors to Affective Illness and PTSD: Potential Neurobiological Mechanisms and Theoretical Implications
- 21 Neurohormonal Aspects of the Development of Psychotic Disorders
- Index
- References
18 - Genesis and Epigenesis of Psychopathology in Children with Depressed Mothers: Toward an Integrative Biopsychosocial Perspective
Published online by Cambridge University Press: 10 August 2009
- Frontmatter
- Contents
- List of Contributors
- Preface
- NEURODEVELOPMENTAL MECHANISMS IN PSYCHOPATHOLOGY
- Part One Basic Mechanisms in Prenatal, Perinatal, and Postnatal Neurodevelopmental Processes and Their Associations with High-Risk Conditions and Adult Mental Disorders
- Part Two Animal Models of Neurodevelopment and Psychopathology
- Part Three Models of the Nature of Genetic and Environmental Influences on the Developmental Course of Psychopathology
- Part Four The Neurodevelopmental Course of Illustrative High-Risk Conditions and Mental Disorders
- 17 Neurobiology of Personality Disorders: Implications for a Neurodevelopmental Model
- 18 Genesis and Epigenesis of Psychopathology in Children with Depressed Mothers: Toward an Integrative Biopsychosocial Perspective
- 19 The Neurobiology of Child and Adolescent Depression: Current Knowledge and Future Directions
- 20 Psychosocial Stressors as Predisposing Factors to Affective Illness and PTSD: Potential Neurobiological Mechanisms and Theoretical Implications
- 21 Neurohormonal Aspects of the Development of Psychotic Disorders
- Index
- References
Summary
Even if scientists uncover a single, powerful determinant of behavior, whether it be a gene linked to a disorder, a toxic biological event that goes awry during fetal development, or an aspect of parental caregiving that interferes with the development of healthy relationships, it is now clear that not all individuals who share such risks will emerge with the same degree of mental health or disorder nor stay on the same, predicted developmental trajectory. In particular, little attention has been paid to the role of neurodevelopmental processes in enhancing or decreasing the opportunity for healthy development in individuals with environmental or genetic risks and vice versa. If we accept that neither environmental qualities nor genes or other biological mechanisms directly determine behavior or developmental course, then we are challenged to consider the potential explanatory power of the complexities of their possible interplay.
It is the purpose of this chapter to accept the challenge of such an integrative perspective for the understanding of risk for the development of psychopathology or other adverse outcomes in children with depressed mothers. Specifically, this chapter will examine current knowledge on outcomes and mechanisms of risk to children with depressed mothers from this perspective and propose future directions for such integrative research. An effort will be made to explore the influences on outcomes not only as a static event but also on alternative developmental pathways.
It needs to be stated at the outset that ideas about complex determinants of behavior are not new.
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- Neurodevelopmental Mechanisms in Psychopathology , pp. 428 - 460Publisher: Cambridge University PressPrint publication year: 2003
References
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