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28A - There Is No Need to Take Embryos Out of the Incubator until the Day of Embryo Transfer

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from Section IV - Embryology

Published online by Cambridge University Press:  25 November 2021

Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

Blastocyst transfer is now the norm for the majority of women undergoing a fresh IVF/ICSI cycle as there is a good amount of evidence to show that this enhanced embryo selection increases the chance of pregnancy per embryo transfer. The culture environment is critical for embryo development, and recent studies using single step media combined with time-lapse incubators have demonstrated an increase in clinical pregnancy rates. This may in part be due to the use of morphokinetic data to enhance selection of the embryo for transfer. However an increase in cumulative pregnancy rates suggests that undisturbed culture may contribute to this uplift. As the cleavage grade of the embryo is not always predictive of blastocyst development, it is not therefore beneficial to remove the embryos from their stable culture environment.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2021

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References

Glujovsky, D, Farquhar, C, Quinteiro Retamar, AM, Alvarez Sedo, CR, Blake, D. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev. 2016; Issue 6. Art.No.: CD002118. DOI: 10.1002/14651858.CD002118.pub5.CrossRefGoogle Scholar
Ciray, HN, Aksoy, T, Goktas, C, Ozturk, B, Bahecci, M. Time lapse evaluation of human embryo development in single versus sequential culture media – a sibling oocyte study. J Assist Reprod Genet. 2012;29:891900.CrossRefGoogle ScholarPubMed
Mascarenhas, M, Fox, SJ, Thompson, K, Balen, AH. Cumulative live birth rates and perinatal outcomes with the use of time lapse imaging incubators for embryo culture: a retrospective cohort study of 1882 ART cycles. BJOG. 2018; https://doi.org/10.1111/1471-0528.15161.CrossRefGoogle Scholar
Swain, JE, Carrell, D, Cobo, A, Messeuger, M, Rubio, C, Smith, GD. Optimising the culture environment and embryo manipulation to help maintain embryo developmental potential. Fertil Steril. 2016;105:571–87.CrossRefGoogle Scholar
Van, HK, Segal, T, Epstein, D, Liu, J, Rossi, B, Goldfarb, J. Predicting blastulation rate with day 2 and 3 morphology: evaluation of cost limited embryo assessment. Fertil Steril. 2018;109(3) sup e54–5.CrossRefGoogle Scholar

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