Book contents
- 50 Big Debates in Reproductive Medicine
- Series page
- 50 Big Debates in Reproductive Medicine
- Copyright page
- Contents
- Contributors
- Foreword
- Introduction
- Section I Limits for IVF
- Section II IVF Add-ons
- Section III The Best Policy
- Section IV Embryology
- 24A ICSI Should Be Used for All IVF Cycles
- 24B ICSI Should Be Used for All IVF Cycles
- 25A Embryo Morphokinetic Analysis (Time-Lapse Imaging) Is Helpful in Selecting Euploid Blastocysts
- 25B Embryo Morphokinetic Analysis (Time-Lapse Imaging) Is Helpful in Selecting Euploid Blastocysts
- 26A Time-Lapse Imaging Should Be a Routine Procedure in Clinical Embryology
- 26B Time-Lapse Imaging Should Be a Routine Procedure in Clinical Embryology
- 27A Artificial Intelligence Is Useful for Embryo Selection in IVF
- 27B Artificial Intelligence Is Useful for Embryo Selection in IVF
- 28A There Is No Need to Take Embryos Out of the Incubator until the Day of Embryo Transfer
- 28B There Is No Need to Take Embryos Out of the Incubator until the Day of Embryo Transfer
- 29A Blastocyst Culture Should Be a Routine in All IVF Cycles
- 29B Blastocyst Culture Should Be a Routine in All IVF Cycles
- Section V Ethics and Statistics
- Section VI Male-factor Infertility
- Section VII Genetics
- Section VIII Ovarian Stimulation
- Section IX Hormones and the Environment
- Index
- References
28A - There Is No Need to Take Embryos Out of the Incubator until the Day of Embryo Transfer
For
from Section IV - Embryology
Published online by Cambridge University Press: 25 November 2021
Book contents
- 50 Big Debates in Reproductive Medicine
- Series page
- 50 Big Debates in Reproductive Medicine
- Copyright page
- Contents
- Contributors
- Foreword
- Introduction
- Section I Limits for IVF
- Section II IVF Add-ons
- Section III The Best Policy
- Section IV Embryology
- 24A ICSI Should Be Used for All IVF Cycles
- 24B ICSI Should Be Used for All IVF Cycles
- 25A Embryo Morphokinetic Analysis (Time-Lapse Imaging) Is Helpful in Selecting Euploid Blastocysts
- 25B Embryo Morphokinetic Analysis (Time-Lapse Imaging) Is Helpful in Selecting Euploid Blastocysts
- 26A Time-Lapse Imaging Should Be a Routine Procedure in Clinical Embryology
- 26B Time-Lapse Imaging Should Be a Routine Procedure in Clinical Embryology
- 27A Artificial Intelligence Is Useful for Embryo Selection in IVF
- 27B Artificial Intelligence Is Useful for Embryo Selection in IVF
- 28A There Is No Need to Take Embryos Out of the Incubator until the Day of Embryo Transfer
- 28B There Is No Need to Take Embryos Out of the Incubator until the Day of Embryo Transfer
- 29A Blastocyst Culture Should Be a Routine in All IVF Cycles
- 29B Blastocyst Culture Should Be a Routine in All IVF Cycles
- Section V Ethics and Statistics
- Section VI Male-factor Infertility
- Section VII Genetics
- Section VIII Ovarian Stimulation
- Section IX Hormones and the Environment
- Index
- References
Summary
Blastocyst transfer is now the norm for the majority of women undergoing a fresh IVF/ICSI cycle as there is a good amount of evidence to show that this enhanced embryo selection increases the chance of pregnancy per embryo transfer. The culture environment is critical for embryo development, and recent studies using single step media combined with time-lapse incubators have demonstrated an increase in clinical pregnancy rates. This may in part be due to the use of morphokinetic data to enhance selection of the embryo for transfer. However an increase in cumulative pregnancy rates suggests that undisturbed culture may contribute to this uplift. As the cleavage grade of the embryo is not always predictive of blastocyst development, it is not therefore beneficial to remove the embryos from their stable culture environment.
- Type
- Chapter
- Information
- 50 Big Debates in Reproductive Medicine , pp. 147 - 148Publisher: Cambridge University PressPrint publication year: 2021
References
Glujovsky, D, Farquhar, C, Quinteiro Retamar, AM, Alvarez Sedo, CR, Blake, D. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev. 2016; Issue 6. Art.No.: CD002118. DOI: 10.1002/14651858.CD002118.pub5.CrossRefGoogle Scholar
Ciray, HN, Aksoy, T, Goktas, C, Ozturk, B, Bahecci, M. Time lapse evaluation of human embryo development in single versus sequential culture media – a sibling oocyte study. J Assist Reprod Genet. 2012;29:891–900.CrossRefGoogle ScholarPubMed
Mascarenhas, M, Fox, SJ, Thompson, K, Balen, AH. Cumulative live birth rates and perinatal outcomes with the use of time lapse imaging incubators for embryo culture: a retrospective cohort study of 1882 ART cycles. BJOG. 2018; https://doi.org/10.1111/1471-0528.15161.CrossRefGoogle Scholar
Swain, JE, Carrell, D, Cobo, A, Messeuger, M, Rubio, C, Smith, GD. Optimising the culture environment and embryo manipulation to help maintain embryo developmental potential. Fertil Steril. 2016;105:571–87.CrossRefGoogle Scholar
Van, HK, Segal, T, Epstein, D, Liu, J, Rossi, B, Goldfarb, J. Predicting blastulation rate with day 2 and 3 morphology: evaluation of cost limited embryo assessment. Fertil Steril. 2018;109(3) sup e54–5.CrossRefGoogle Scholar