Book contents
- 50 Big Debates in Reproductive Medicine
- Series page
- 50 Big Debates in Reproductive Medicine
- Copyright page
- Contents
- Contributors
- Foreword
- Introduction
- Section I Limits for IVF
- Section II IVF Add-ons
- Section III The Best Policy
- Section IV Embryology
- Section V Ethics and Statistics
- Section VI Male-factor Infertility
- Section VII Genetics
- Section VIII Ovarian Stimulation
- Section IX Hormones and the Environment
- 45A Metformin Is an Effective Treatment for Infertility Associated with Anovulatory PCOS
- 45B Metformin Is an Effective Treatment for Infertility Associated with Anovulatory PCOS
- 46A Laparoscopic Ovarian Drilling Should Be Performed for CC-Resistant PCOS
- 46B Laparoscopic Ovarian Drilling Should Be Performed for CC-Resistant PCOS
- 47A Asymptomatic Polycystic Ultrasound Appearance of the Ovary Is Favourable for IVF Outcome
- 47B Asymptomatic Polycystic Ultrasound Appearance of the Ovary Is Favourable for IVF Outcome
- 48A Ultrasound Monitoring Is Not Required for Letrozole Treatment
- 48B Ultrasound Monitoring Is Not Required for Letrozole Treatment
- 49A Progesterone Levels Should Be Measured on the Day of hCG Administration
- 49B Progesterone Levels Should Be Measured on the Day of hCG Administration
- 50A Progesterone Treatment Does Not Help Recurrent Miscarriage Patients
- 50B Progesterone Treatment Does Not Help Recurrent Miscarriage Patients
- 51A The Microbiome Environment Influences IVF Results
- 51B The Microbiome Environment Influences IVF Results
- Index
- References
49A - Progesterone Levels Should Be Measured on the Day of hCG Administration
For
from Section IX - Hormones and the Environment
Published online by Cambridge University Press: 25 November 2021
Book contents
- 50 Big Debates in Reproductive Medicine
- Series page
- 50 Big Debates in Reproductive Medicine
- Copyright page
- Contents
- Contributors
- Foreword
- Introduction
- Section I Limits for IVF
- Section II IVF Add-ons
- Section III The Best Policy
- Section IV Embryology
- Section V Ethics and Statistics
- Section VI Male-factor Infertility
- Section VII Genetics
- Section VIII Ovarian Stimulation
- Section IX Hormones and the Environment
- 45A Metformin Is an Effective Treatment for Infertility Associated with Anovulatory PCOS
- 45B Metformin Is an Effective Treatment for Infertility Associated with Anovulatory PCOS
- 46A Laparoscopic Ovarian Drilling Should Be Performed for CC-Resistant PCOS
- 46B Laparoscopic Ovarian Drilling Should Be Performed for CC-Resistant PCOS
- 47A Asymptomatic Polycystic Ultrasound Appearance of the Ovary Is Favourable for IVF Outcome
- 47B Asymptomatic Polycystic Ultrasound Appearance of the Ovary Is Favourable for IVF Outcome
- 48A Ultrasound Monitoring Is Not Required for Letrozole Treatment
- 48B Ultrasound Monitoring Is Not Required for Letrozole Treatment
- 49A Progesterone Levels Should Be Measured on the Day of hCG Administration
- 49B Progesterone Levels Should Be Measured on the Day of hCG Administration
- 50A Progesterone Treatment Does Not Help Recurrent Miscarriage Patients
- 50B Progesterone Treatment Does Not Help Recurrent Miscarriage Patients
- 51A The Microbiome Environment Influences IVF Results
- 51B The Microbiome Environment Influences IVF Results
- Index
- References
Summary
Although the impact of high serum P levels the day of triggering on IVF cycle outcome has been extensively reported, its determination is not fully implemented in daily practice. Indeed, some authors argue that this is not justified. In this text you´ll find a different approach to the analysis of the causal-effect relation of serum P and cycle outcome, to demonstrate that P levels should be measured on the day of hCG administration, when a fresh embryo transfer is planned. The 9 Bradford–Hill criteria described to analyze the potential cause–effect relation between two events are reviewed, and moreover, shown to be accomplished by the relationship between high serum P levels and pregnancy rates. Therefore, it is concluded that a simple low-cost practice as serum P determination leads to significant improvement of cycle outcome, and consequently both patients’ and practitioners’ satisfaction.
- Type
- Chapter
- Information
- 50 Big Debates in Reproductive Medicine , pp. 254 - 256Publisher: Cambridge University PressPrint publication year: 2021
References
Hill, AB. The environment and disease: association or causation? Proc Royal Soc Med. 1965;58:295–300.CrossRefGoogle ScholarPubMed
Venetis, CA, Kolibianakis, EM, Bosdou, JK, Tarlatzis, BC. Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60,000 cycles. Hum Reprod Update. 2013;19:433–57.CrossRefGoogle Scholar
Bosch, E, Labarta, E, Crespo, J, et al. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod. 2010;5:2092–100.Google Scholar
Labarta, E, Mariani, G, Holtmann, N, Celada, P, Remohí, J, Bosch, E. Low serum progesterone on the day of embryo transfer is associated with a diminished ongoing pregnancy rate in oocyte donation cycles after artificial endometrial preparation: a prospective study. Hum Reprod. 2017;32:2437–42.CrossRefGoogle ScholarPubMed
Bosch, E, Valencia, I, Escudero, E, et al. Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its relationship with in vitro fertilization outcome. Fertil Steril. 2003;80:1444–9.CrossRefGoogle ScholarPubMed