The present study investigated the relations between youth anxiety sensitivity and perceived anxiety control over Internal Reactions and perceived anxiety control over External Threats within the context of a (partially) mediated model in the prediction of anxiety symptoms. Youth sex also was investigated as a moderator of the conceptual model. The sample consisted of 333 children and adolescents (51.4% boys; M = 10.27 years old) referred to a youth anxiety disorders specialty research clinic. Findings showed that high anxiety sensitivity predicted high levels of anxiety symptoms for both boys and girls. Findings also showed that for both boys and girls, high anxiety sensitivity predicted low perceived anxiety control over Internal Reactions, as well as low perceived anxiety control over External Threats. Interestingly, perceived anxiety control over Internal Reactions was a partial mediator of the relation between anxiety sensitivity and anxiety for boys, but not girls. In contrast, perceived anxiety control over External Threats was a partial mediator of the relation between anxiety sensitivity and anxiety for girls, but not boys. The results are discussed within the context of the study's conceptual model as well as potential clinical implications.