Proso millet is a short-season summer annual grass that is well adapted to the central Great Plains. Proso millet is commonly planted as a summer crop when winter wheat stands are lost due to adverse conditions. Sulfonylurea herbicides labeled for use in winter wheat prohibit planting proso millet for intervals up to 10 mo following application. A series of greenhouse and field studies determined proso millet tolerance to CGA-152005, metsulfuron, and triasulfuron soil residue. In the greenhouse, proso millet was not affected by soil-applied CGA-152005 at doses up to 160 g ai/ha, while metsulfuron and triasulfuron doses of 4 and 15 g ai/ha, respectively, inhibited proso millet biomass accumulation. In the field, metsulfuron and triasulfuron caused early season stunting and chlorosis at doses two to four times those recommended; however, grain yields were not affected. Organic matter and clay content were highly correlated with proso millet growth response to the herbicides under greenhouse conditions, but in the field, soil pH may have influenced herbicide bioavailability.