Glyphosate-resistant Palmer amaranth has become a major threat to soybean production in the southern United States. Arkansas soybean producers rely heavily on glyphosate-resistant soybean; hence, an alternative solution for controlling resistant Palmer amaranth is needed. A field experiment was conducted at Marianna, AR, during 2009 and 2010 in which soybean production systems were tested in combination with deep tillage and no tillage to determine the impact on Palmer amaranth emergence. To establish a baseline population, 250,000 glyphosate-resistant Palmer amaranth seeds were placed in a 1-m2 area in the middle of each plot and incorporated in the soil, and emergence was evaluated five times during the season. Production systems of full-season soybean with a rye cover crop or soybean double-cropped with wheat, which had high amounts of plant residue on the soil surface reduced Palmer amaranth emergence more than systems without deep tillage and a cover crop or wheat. When used in combination with deep tillage, these systems reduced Palmer amaranth emergence by 98 and 97%, respectively, in 2009 and by 73 and 82%, respectively, in 2010. Deep tillage alone caused an 81% reduction in emergence averaged over both years. Soybean double-cropped with wheat used in combination with deep tillage provided a 95% reduction in Palmer amaranth emergence over the 2-yr period. This research shows that deep tillage in combination with soybean production systems that have high amounts of residue on the soil surface are alternative means for providing a high level of control of glyphosate-resistant Palmer amaranth and could lessen the dependence on chemical weed control.