This chapter discusses how quality of life (QOL) may be disrupted by epilepsy. It provides suggestions about how to communicate the QOL concerns to the health-care team. The medical profession has only recently moved toward appreciating that health-related QOL (HRQOL) is an important component in assessing the effectiveness of health care. Five general domains can be used to describe HRQOL: physical condition; psychological condition; vocational (work) capacity; social function; and disease-specific conditions. Several questionnaires have been developed that allow people with epilepsy to express their concerns about the variety of issues that affect their lives. The use of HRQOL assessment as part of routine assessment for people with epilepsy gives them the opportunity to respond to direct questions about all major aspects of living with epilepsy. HRQOL scores can be considered a new measure of overall patient function, like blood levels for antiepileptic drugs (AED).