The effect of two dates of initial manual weeding, i.e., before flowering and after flowering, and of no weeding on yield of a local groundnut variety was studied during 1988 and 1989 at Minkoameyos, Yaounde, Cameroon, in comparison with chemical weed control method or control. The use of herbicides ametryn plus promotryn for weed control gave the best mean yield, followed by handweeding after flowering, and handweeding before flowering, in that order. The no weeding treatment had the lowest yield throughout the trial period.