In this article, I choose struggles over skill development as an entry point to uncovering features of women's labor activism in state-owned tobacco factories in Romania, from the 1920s to the early 1960s. I look at the processes that constructed women tobacco workers, especially those at the Tobacco Manufactory in the city of Cluj, as non-skilled workers, and examine the forms of labor activism in the tobacco industry that challenged those constructs. I describe how women's work at the Cluj Tobacco Manufactory, from the mid-1920s to the mid-1950s, was shaped by successive waves of production intensification and rationalization, demonstrating that these reorganizations affected female workers more than they affected their male coworkers. I point out that although they were considered non-skilled laborers, female tobacco workers exercised an amount of control over their work and were important contributors to their families’ maintenance. I show that spanning two different political regimes, matters of skill were at the core of labor activism. For female workers, in the interwar period, labor activism in male-dominated organizations and structures entailed skill-mediated political strategies that emphasized experience and shopfloor status besides skill. By the 1950s, labor activism encompassed engaging in confrontational politics over seasoned women workers’ lack of access to skill training programs. I show that both in the late 1920s and in the early 1950s, illiteracy and women's more limited access to formal schooling in general shaped new experiences of participation in labor politics.