The importance of selenium as a key component of antioxidant systems in animals is well recognised due to much research about this mineral in many species. Selenium is required as part of the antioxidant enzyme structure and plays a major role in various protective systems in animal physiology, including immunity, cellular stability and DNA protection. The following review is the first in a series of three which details the importance of selenium in animal nutrition, and how the chemically organic form, which is akin to the form of the mineral in natural feed materials, can provide increased benefits in utilisation, storage and metabolism compared to inorganic sources.