Establishment of seedlings of big sagebrush subsequent to range weed control treatments limits the economic feasibility of such treatments for increased forage production. This study investigated the dynamics of seed production by this species as one step in understanding seedling establishment. Studies were conducted on five different ecological sites along the arid extremity of big sagebrush distribution in western Nevada. Demography, physical dimensional parameters, biomass, and community structure were determined for each site and related to seed production over a 4-yr period. In addition, seeds harvested from each site were used to grow plants that were transplanted to establish reciprocal gardens at all sites. Seeds were subsequently harvested from the plants in these gardens. The average stand studied was capable of producing about 50 million seeds/ha annually. The plant characteristics most closely correlated with seed production were leaf weight, canopy density, and root crown diameter. The stand that consistently had the highest average seed production had the lowest woody biomass accumulation rate. In reciprocal gardens, plants grown from this stand had the highest average seed production. Seed production of big sagebrush plants appears to be related to site characteristics, shrub biomass characteristics, and inherent genetic potential of the plants in a given collection.