Sugarcane growers have observed reduced residual activity of atrazine on organic soils in the Everglades Agricultural Area (EAA) of south Florida. Field studies were conducted between 2011 and 2012 to determine the rate of dissipation of atrazine at 2.24, 4.48, and 8.96 kg ha−1 and metribuzin at 0.56, 1.12, and 2.24 kg ha−1 in the top 10 cm of soil in sugarcane fields in the EAA. The bioavailable fraction of atrazine dissipated more rapidly than the total amount of atrazine in the soil. Half-lives of the total and bioavailable fraction of atrazine ranged between 3.9 to 12.1 d and 1.0 to 7.5 d, respectively. Metribuzin dissipated much more slowly than atrazine on organic soils. Similarly, dissipation of the bioavailable fraction of metribuzin was more rapid than was the dissipation of the total amount of metribuzin in the soil. Half-lives of the total and bioavailable fraction of metribuzin ranged between 16.2 and 24.8 d and 6.0 and 14.3 d, respectively. These results indicate that enhanced atrazine degradation occurs on organic soils under field conditions in the EAA, resulting in shorter residual atrazine activity. This implies that metribuzin is a better option for weed control in sugarcane grown on organic soils of the EAA exhibiting enhanced atrazine degradation.