Thirty-five pearl millet cultivars of short, medium and long maturity cycle were screened in Senegal during 1985–1986 crop seasons to study field reaction to the attack of stalk borer, Coniesta (Acigona) ignefusalis Hmps.; spike worm, Heliocheilus (Raghuva) albipunctella De Joannis; millet midge, Geromyia penniseti Felt; head smut, Tolysporium penicillariae Bref; and ergot, Claviceps fusiformis Lov. Insect and disease incidence varied considerably depending upon cultivar maturity cycle. Least susceptible cultivars were IBV-8001 and P8 against spike worm; Zalla, NKK, P8 and M2D2 against head smut, and Ex-Darou against ergot. Cultivation of IBV-8001 has been suggested in northern and central Senegal. However, studies on identification and utilization of resistance sources of wide genetic diversity and multilocational tests may be necessary.