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1 results

  • Chapter 23 - Clinical Value of Sperm DNA Fragmentation Tests

  • from Section 4 - Laboratory Evaluation and Treatment of Male Infertility
  • Edited by Douglas T. Carrell, Utah Center for Reproductive Medicine, Alexander W. Pastuszak, University of Utah, James M. Hotaling, Utah Center for Reproductive Medicine
  • Book:
    Men's Reproductive and Sexual Health Throughout the Lifespan
    Published online:
    06 December 2023
    Print publication:
    16 November 2023, pp 183-190

  • Summary

    Over the past 20 years, there has been growing interest in understanding the genomic integrity of human spermatozoa and the clinical relevance of sperm chromatin and DNA defects. We have learned that the etiology of human sperm DNA damage is multi-factorial and that sperm DNA defects are associated with abnormal semen parameters. While we have observed that tests of sperm DNA integrity are correlated with reproductive outcomes, use of these complementary biomarkers in the management of male infertility remains controversial. In this chapter, we review the etiologic factors associated with sperm DNA damage and the utility of these tests in clinical practice. We also review the treatment options for infertile men with sperm DNA damage.