Imazethapyr at 0.05 to 0.14 kg ai/ha applied preplant incorporated, preemergence, and postemergence was evaluated alone and with complementary herbicides in the field for weed control in soybean. Imazethapyr controlled 90% or more smooth pigweed regardless of application method or herbicide rate. Imazethapyr at 0.05 kg/ha controlled jimsonweed 30% better postemergence compared to soil applications. Imazethapyr at 0.10 kg/ha controlled 90% or more velvetleaf regardless of application method. The addition of alachlor to soil-applied imazethapyr enhanced giant foxtail, jimsonweed, and velvetleaf control. Adding acifluorfen or bentazon to postemergence imazethapyr antagonized weed control. Adding sethoxydim to postemergence imazethapyr was not beneficial.