In these polarized and challenging times, not even perceptions of personal risk are immune to partisanship. This article introduces results from a new survey with an embedded social media experiment conducted during the first months of the COVID-19 pandemic in Brazil. Descriptive results show that progovernment and opposition partisans report very different expectations of health and job risks. Job and health policy have become wedge issues that elicit partisan responses. The analysis exploits random variation in the survey recruitment to show the effects of the president’s first speech on national television on the perceived risk and the moderating effect of partisanship. The article presents a framing experiment that models key cognitive mechanisms driving partisan differences in perceptions of health risks and job security during the COVID-19 crisis.