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1 results

  • Epstein–Barr virus-associated smooth muscle tumour mimicking bilateral vocal process granuloma

  • E C Gan, D P C Lau, K L Chuah
  • Journal:
    The Journal of Laryngology & Otology / Volume 122 / Issue 1 / January 2008
    Published online by Cambridge University Press:
    20 April 2007, pp. 100-104
    Print publication:
    January 2008

  • A case is presented of a 36-year-old Chinese woman with a renal transplant for end-stage renal failure due to Goodpasture's syndrome. She presented with a year's history of throat discomfort and acid regurgitation into her throat. Videolaryngoscopy revealed bilateral vocal process granuloma, presumed to be due to gastroesophageal reflux. A four-week course of high dose omeprazole was prescribed. On follow up a month later, the granulomas had enlarged, and laser excision was undertaken. Histological and immunohistochemical staining was consistent with Epstein–Barr virus-associated smooth muscle tumour. This is believed to be the first reported case in the English literature of such a tumour affecting the vocal process. The aim of this paper is to present the pathogenesis, clinical behaviour and treatment of Epstein–Barr virus-associated smooth muscle tumour, and to review the literature concerning the differential diagnosis of polypoid vocal process lesions.