The influence of various factors on the tolerance of corn and selected weed species to thifensulfuron was studied in greenhouse experiments. Corn fresh weight was reduced by postemergence application of thifensulfuron when applied at 180 g ai ha−1 without surfactant or at 18 g ha−1 with a nonionic surfactant. Corn was more susceptible to root exposure whereas velvetleaf was more susceptible to foliar exposure. Velvetleaf was most susceptible when plants were young, when a nonionic surfactant was added, and at 20 rather than 30 C. Simulated rainfall 8 h after application reduced velvetleaf injury by thifensulfuron at 18 g ha−1 without surfactant; however, with addition of a nonionic surfactant, velvetleaf injury was reduced only if rainfall occurred less than 2 h after application. Soil moisture level did not affect velvetleaf susceptibility.