Our studies are motivated by a desire to model long-time simulations of possible scenarios for a waste disposal. Numerical methods aredeveloped for solving the arising systems of convection-diffusion-dispersion-reactionequations, and the received results of several discretizationmethods are presented. We concentrate on linear reaction systems, which can be solved analytically.In the numerical methods, we use large time-steps to achievelong simulation times of about 10 000 years.We propose higher-order discretization methods, which allow us to use large time-steps without losing accuracy.By decoupling of a multi-physical and multi-dimensional equation,simpler physical and one-dimensional equations are obtained and can be discretized with higher-order methods. The results can then be coupled with an operator-splitting method.We discuss benchmark problems given in the literature and real-life applications.We simulate a radioactive waste disposals with underlying flowing groundwater.The transport and reaction simulations for the decay chains are presentedin 2d realistic domains, and we discuss the received results.Finally, we present our conclusions and ideas for further works.