During Miguel de Cervantes' lifetime, the Mediterranean World was suffering a transformation in the internal distribution of power, both political and economic. Although the Ottoman fleet was defeated, which established the limits of dominance between the two empires, this did not prevent the entry in this space of the new commercial powers from northern Europe, which changed the trade in the Mediterranean. This article tries to provide a synthesis of this process, of which Cervantes was a direct witness both in his personal life and through the works which have survived to our time.