This study examines the late seventeenth-century reception of enthusiasm in England in the context of the contemporary epistemological debate. Challenging characterizations of responses to enthusiasm as partitioned along the rationalist-empiricist divide, I show how parallel critiques of enthusiasm by natural philosophers and theologians suggest shared epistemic commitments across methodological and disciplinary boundaries, reflecting evolving concerns in the broader epistemological debate, rather than fixed, domain- or ideology-specific positions. By challenging a crude rationalist-empiricist division, this study aligns itself with previous literature, while also departing from it, in that it locates in the critique of enthusiasm a previously under-examined facet of that debate. By showing that both natural philosophers and theologians rejected enthusiasm for its irrationality, this work also sharpens the current understanding of the epistemic significance of enthusiasm, in that it identifies the crux of the critique of enthusiasm in its lack of reason, and not of an empirical foundation.