Saturn’s moon Titan was explored by the Cassini mission for nearly 13 years. Important discoveries made during the Cassini mission include the observations of stratospheric clouds in Titan’s cold polar regions in which spectral features or organic molecules were detected in the infrared (<100 μm). In particular, benzene (C6H6) ice spectral signatures were recently detected at unexpectedly high altitudes over the South Pole. The combined experimental, modeling and observational effort presented here has been devised and executed in order to interpret these high altitude benzene observations. Our multi-disciplinary approach aims to understand and characterize the microphysics of benzene clouds in Titan’s South Pole.