Two experiments were conducted to determine the most effective herbicide treatments for fringed sagebrush (Artemisia frigida Willd.) control in rangelands. In the first study the potassium salt of picloram (4-amino-3,5,6-trichloropicolinic acid) at 0.1, 0.6, and 0.8 kg/ha; picloram + the propylene glycol butyl ether ester of 2,4-D [(2,4-dichlorophenoxy)acetic acid] at 0.1 + 1.1 kg/ha; the monoethanolamine salt of 3,6-dichloropicolinic acid at 1.1 kg/ha; 3,6-dichloropicolinic acid + 2,4-D at 0.6 + 1.1 kg/ha; and the dimethylamine salt of dicamba (3,6-dichloro-o-anisic acid) + 2,4-D at 0.6 + 1.1 kg/ha applied in late summer at flowering, showed the greatest potential for fringed sagebrush control. In the second experiment, the potassium salt of picloram at 0.3 kg/ha applied either in the spring or late summer gave 94 to 100% fringed sagebrush control, respectively, 1 yr after application. Control of fringed sagebrush had declined to 50% 3 yr after application. Production of perennial grasses from plots receiving picloram at 0.3 kg/ha in 1976 was increased by 410 kg/ha in 1977, 450 kg/ha in 1978, and 430 kg/ha in 1979 over that of the untreated plots.