Health promotion and participatory research present challenges and opportunities for extending the benefits of science to populations who have not fully benefited from innovations available through self-care and mutual aid. This paper illustrates some of the strengths, weaknesses, issues and problems in applying the approaches of health promotion and participatory research with First Nations populations for purposes of arthritis self-management. We suggest ways in which these experiences apply to the elderly. Preliminary results from our First Nations Arthritis Self-Management study illustrate participatory research and promising outcomes. The adaptability of these health promotion strategies in the First Nations community can be generalized to the elderly in the general population based on their common experience with arthritis and the advantages of participatory planning with distinguishable demographic groups who share a common identity.