Clopyralid (3,6-dichloro-2-pyridinecarboxylic acid) was superior to 2,4,5-T [(2,4,5-trichlorophenoxy)acetic acid], dicamba (3,6-dichloro-o-anisic acid), picloram (4-amino-3,5,6-trichloropicolinic acid), and triclopyr {[(3,5,6-trichloro-2-pyridinyl)oxy] acetic acid} for control of honey mesquite (Prosopis glandulosa Torr. ♯ PRCJG) in the field. However, equal ratio mixtures of clopyralid + picloram or triclopyr (0.28 + 0.28 or 0.56 + 0.56 kg ae/ha) were as effective for honey mesquite control as clopyralid at rates of 0.56 and 1.12 kg/ha. Equal mixtures of picloram + 2,4,5-T, picloram + triclopyr, picloram + dicamba, triclopyr + 2,4,5-T, or triclopyr + dicamba were less effective in controlling honey mesquite than clopyralid alone or clopyralid + picloram or triclopyr in 1:1 mixtures. In the greenhouse, mixtures of clopyralid + 2,4,5-T, picloram, or triclopyr were highly effective for the control of honey mesquite. Mixtures of 2,4,5-T + picloram, 2,4,5-T + triclopyr, or triclopyr + picloram were also effective when applied at 0.28 + 0.28 kg/ha.