In this chapter, we discuss the notion of a quantum simulator as a device that emulates a complex quantum many-body Hamiltonian, and a quantum annealer as an extension of such a paradigm that focuses on the preparation of the ground state in those Hamiltonians. Starting from the Landau–Zener processes and the adiabatic theorem, we illustrate how such ground states can be prepared by slow (adiabatic) deformations of a Hamiltonian. We discuss how this results in an adiabatic quantum computing algorithm and how, depending on the Hamiltonian we apply it to, we can solve problems of different classical and quantum complexity. The chapter closes with a thorough discussion of the D-Wave quantum annealer as a real-world superconducting quantum simulator of Ising-type models. This discussion centers both on the design of the superconducting annealers as well as on the conclusion from the literature on how this device works in practice, including how quantum operations are still possible even in the pressence of decoherence. We close the chapter with an outlook on the challenges that need to be overcome for making coherent quantum annealers and universal adiabatic quantum computers.