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protein l

Protein Science (1)

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Robustness of protein folding kinetics to surface hydrophobic substitutions
H. GU, N. DOSHI, D.E. KIM, K.T. SIMONS, J.V. SANTIAGO, S. NAULI, DAVID BAKER
Journal:

Protein Science / Volume 8 / Issue 12 / December 1999

Published online by Cambridge University Press:

01 December 1999, pp. 2734-2741

Print publication:

December 1999
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We use both combinatorial and site-directed mutagenesis to explore the consequences of surface hydrophobic substitutions for the folding of two small single domain proteins, the src SH3 domain, and the IgG binding domain of Peptostreptococcal protein L. We find that in almost every case, destabilizing surface hydrophobic substitutions have much larger effects on the rate of unfolding than on the rate of folding, suggesting that nonnative hydrophobic interactions do not significantly interfere with the rate of core assembly.