The role indigenous livestock can play in Africa's Livestock Revolution is not always recognized. In many parts of Africa pure breeding with indigenous breeds is the only viable production strategy because of adverse climatic and nutritional conditions. However, there are scenarios where the higher demands of exotic breeds and their cross-breds can be met. This article discusses the possibility of improving beef production through terminal cross-breeding with two South African cattle breeds, the Nguni and the Afrikaner, with different exotic breeds. Calving difficulties were limited and birth weights were restricted to the mid-parent value or below. Cross-breeding did not have a negative effect on cow performance such as weight change and fertility, but cow productivity increased. In most cases the weaning weight of cross-bred calves was the same or exceeded that of the pure sire breed, and the feed conversion ratio was always better than either of the two parent breeds. This made the feedlot performance of the cross-breds highly desirable. These results indicate that terminal cross-breeding with indigenous African breeds deserves more attention as a means of increasing the output of beef cattle in the subtropics and tropics. An added advantage of any system of terminal cross-breeding utilizing indigenous breeds is that the conservation and utilization of the indigenous breeds of Africa is ensured, because a constant stream of purebred females will be required.