The Antarctic oscillation (AAO) has been characterized by a persistently positive trend in summer (December–January–February, DJF) during the last 50 years. Thus, the question has arisen of whether the trend is unusual. By investigating five reconstructed historical AAO time series for the past 500 years, recurrences of similar and even stronger trends have been found, indicating that the recent DJF AAO trend is not unprecedented in a historical perspective. To estimate the possible roles played by greenhouse gases or/and ozone, an analysis for DJF AAO trends during the 1969–98 period was conducted using three multiple model ensembles derived from the projects of ‘The twentieth-century climate in coupled models’ (20C3M) and ‘Pre-industrial control experiment models’ (PICTL) of the fourth assessment report of the Intergovernmental Panel on Climate Change (IPCC AR4). The results show that the ozone depletion over Antarctica and global warming may play significant roles in the strengthening trend. Combining the simulations and reconstructions we emphasize that the AAO trend related to global warming may get much stronger when enhanced by low-frequency natural variability.