This article reviews the use of portable microscopes in published science from Antonie van Leeuwenhoek's letters to the Royal Society to a recent paper on the phylogeny of the phorid fly by Hartop et al. [1]. The portability of a pocket microscope is a clear benefit, yet bulky compound microscopes remain the mainstay of field research and diagnosis. There is a growing interest in the impact of climate change, which drives researchers to investigate the smallest, most fragile life in remote places such as Antarctica, Mount Everest, and the Amazon Rainforest. Are pocket microscopes ready to produce publication-standard images?