This chapter reviews what we know about scribal practices of orthography (focusing on spelling), how their orthographies have been studied and interpreted, and where avenues of future research lie. It covers fundamental aspects of studying scribes, showing the multidisciplinary interest in scribes and providing a broad background for thinking about scribal variation in orthography. It discusses issues such as the term and concept of a scribe, the contexts in which scribes worked, and how the role of the scribe has changed over time. The chapter focuses on research concerning scribal orthographies within three broad contexts: studies focusing on phonology and phonetics but using scribal orthography as the source of information; research that concentrates on the intersection of phonology/phonetics and orthography; and studies that are interested in orthography as an exclusively or primarily written phenomenon. It also addresses the issue of orthographic standardization specifically, as scribes have been seen as central in this process, and touches on the various frameworks and approaches adopted for the study and interpretation of spelling regularization and standardization. Finally, the chapter points to some of the avenues open for new discoveries in the future.