PRE and POST herbicide options were evaluated to control perilla mint, a potentially deadly plant for livestock. The germination requirements of seed from weedy populations were also investigated to better understand and predict emergence timing. POST applications of aminocyclopyrachlor blends, glyphosate, picloram+2,4-D, aminopyralid+2,4-D, and 2,4-D alone provided superior control of perilla mint when applied in the early reproductive growth stage. Picloram+2,4-D and aminocyclopyrachlor+chlorsulfuron also provided soil residual activity and the most effective PRE control followed by pendimethalin and aminopyralid+2,4-D. Seed from weedy populations tend to germinate in a range of night/day soil temperatures from 10–15 C to 25–30 C. Therefore, application and activation of the most effective PRE treatments should be made before these temperatures occur in areas where weedy perilla mint populations are found.