To date, studies of imprisonment and incarceration have focused on the growth of male-gendered penal institutions. This essay offers a provocative addition to the global study of the prison by tracing the emergence of a carceral system in West Africa in the nineteenth century that was organized around the female body. By examining archival testimonies of female prisoners held in what were called “native prisons” in colonial Gold Coast (southern Ghana), this essay shows how birthing, impregnation, and menstruation shaped West Africa penal practices, including the selection of the captives, the duration of their time in prison, and how the prison factored into the legal infrastructure around tort settlements for debts and crimes. The term “prison of the womb” is used here to describe how the West African prison held bloodlines captive, threatening the impregnation of a female kin member as a ticking clock for tort settlement. Furthermore, it will be shown that this institution was imperative to the spread of mercantile capitalism in nineteenth-century Gold Coast.