The Hannibal of this book is Hannibal surnamed Barca. Scipio is Publius Cornelius Scipio Africanus. The final extra name (‘the African’) was given to him in recognition of his victory over Hannibal in north Africa. The Prologue explains that the model for this joint biograohy of Hannibal and Scipio is not so much Plutarch’s series of parallel Greek and Roman lives, as Alan Bullock’s Hitler and Stalin: Parallel Lives. Ancient, Renaissance, and modern explorations of the parallels between the two men are discussed, and a separate section sketches the career and approach of Bullock as a classically trained modern historian and biographer. Another section sets out programmatically the view of Roman and Carthaginian imperialism to be adopted in the book. The limitations of the evidence available to biographers of individuals from the ancient world are candidly acknowledged, and the use of the ‘past presumptive’ tense (so-and so- ‘will have’ done, known, or thought this or that) is renounced.

The Introduction situates Plutarch in his literary context, as a vivid and original thinker and writer whose popularity remains enormous, as well as his historical context as an innovator in the writing of biography. Some authors discuss Plutarch’s role in the development of the biographical tradition and his relationship to the classical Greek past. Others examine his Roman context as a Greek living in an occupied country, and his views on politics, particularly those involving barbarians or "others." Multiple essays illuminate Plutarch’s relationship to Plato and Platonism, often in the context of his influence on education, while other essays look at Plutarch in his everyday life, investigating his thoughts on gender, sexuality, wealth, and animals. Five essays focus on reception.