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1 results

  • A retrospective analysis: follow up with 18F-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography in oro- and hypopharyngeal squamous cell carcinoma patients

  • Joke Van Nuffel, Katia Verbruggen, Mia Voordeckers, Yannick De Brucker, Nele Platteaux, Ina Foulon, Olaf Michel
  • Journal:
    The Journal of Laryngology & Otology / Volume 138 / Issue 7 / July 2024
    Published online by Cambridge University Press:
    06 September 2023, pp. 747-754
    Print publication:
    July 2024
    • Article
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  • Objective

    This study evaluated the significance of positron emission tomography/computed tomography (PET/CT) in detecting recurrences or other primary malignancies in patients treated for oro- and hypopharyngeal squamous cell carcinoma.

    Method

    A retrospective analysis of the follow up of 132 patients was performed and 370 PET/CT scans were assessed for their accuracy.

    Results

    All asymptomatic clinical occult recurrences were detected by PET/CT and accounted for 28 per cent of recurrences. Asymptomatic patients with metastases detected by PET/CT had a significant survival benefit compared to patients diagnosed in a symptomatic stage. For locoregional recurrence, no significant difference in overall survival could be demonstrated. In total, 33 primary malignancies were discovered, of which 48 per cent were first detected by PET/CT. The specificity and negative predictive value of the PET/CT scans had ranges of 85–100 and 83–100 per cent, respectively.

    Conclusion

    The role of PET/CT scans in detecting primary malignancies, clinical occult recurrences and especially asymptomatic metastases was observed.