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1 results

  • Onset of action under antidepressant treatment

  • H.H. Stassen, J Angst, A Delini-Stula
  • Journal:
    European Psychiatry / Volume 12 / Issue 4 / 1997
    Published online by Cambridge University Press:
    16 April 2020, pp. 163-165

  • The issues of timing in antidepressant treatment are of great theoretical and practical relevance, even more so since recent meta-analyses yielded no evidence for a specific mode of action of antidepressants, which, according to the theory of delayed onset of action, is expected to emerge after 2 weeks of therapy. To address the issues of timing on a methodologically sound basis, future trials should adapt a ‘longitudinal’ rather than ‘cross-sectional’ design, standardized with respect to a washout period, baseline and first 2 week assessments. With this in mind, special attention should be paid to parameters which potentially enable the identification of placebo responders, true drug responders and patients at risk of non-improvement. Results and methods of the Zurich meta-analyses may serve as a starting point for further steps in this direction.