The effectiveness of oxyfluorfen and bromoxynil for Russian thistle control in onion was measured in a 2-yr study conducted in the high desert region of southern California. Oxyfluorfen, bromoxynil, or combinations of the two applied one at the 2-leaf growth stage of onion did not control Russian thistle. When a first application was followed 14 days later with a second herbicide application, a first application of oxyfluorfen plus bromoxynil was most effective. Oxyfluorfen applied alone as a second application was least effective, but bromoxynil alone plus oxyfluorfen improved control. Adding petroleum oil to oxyfluorfen plus bromoxynil improved Russian thistle control.