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nutritional cerebellar degeneration

Cambridge University Press (1)

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Chapter 15 - Wernicke Disease
Robert Laureno, Georgetown University, Washington DC
Book:

Insights into Clinical Neurology

Published online:

27 July 2023

Print publication:

20 July 2023, pp 75-81
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Summary

In the era of MRI we have advanced our knowledge of the topography of Wernicke disease. We have learned that cortical and striatal lesions can occur. Clinical observations have revealed that hearing loss can occur, sometimes with the MRI correlate of involvement of the inferior colliculi. Vestibular signs have been correlated with involvement of the vestibular nuclei. Previously unpublished data show a high incidence of the midline cerebellar lesion in oropharyngeal cancer. Ideas about proper thiamine dosing are discussed.