Reproductive endocrinology and infertility (REI) nursing is a growing, evolving, highly specialized field. The REI nurse anticipates the need to make choices, is able to do so without the assistance from others, yet with personal consideration to those the decision effects, and takes responsibility for them. Informed consent in REI nursing warrants special consideration. Good interpersonal skills create a good nurse-patient relationship. This usually translates into daily and sometimes intense interactions with patients as cycles begin, progress, and finish and pregnancy tests are awaited or are completed. Reproductive medicine may present ethical dilemmas for couples and caregivers and will continue to do so as scientific and technological advances extend faster than existing legal and moral frameworks. Supervisors should endeavor to make staff feel valued and appreciated by word and by deed. Recognition and positive feedback are critical to job satisfaction.