The chapter presents and discusses empirical data on the neuropsychology of gesture production. The focus of this chapter is on the specific contributions of the right and left hemispheres to the generation of gestures. Since the respective neuroscientific method has a substantial impact on the study results and different methodologies can even entail apparently opposing results concerning gesture production, different neuropsychological methods, their paradigms, and limitations are presented in detail. Spontaneous gesture production studies evidence a substantial contribution of the right hemisphere to gesture production, while gesture production on command studies show a relevant role of the left hemisphere. Gestures that are generated in association with right hemispheric functions such as spatial cognition, nonverbal emotional expression, global and metaphorical thinking appear to be generated in the right hemisphere, while gestures that are linked to tool use praxis are generated in the left hemisphere. The findings further provide a neuropsychological basis for understanding the complementarity but also the dissociation between gestural and verbal message.