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In this paper, we are concerned with the following bi-harmonic equation with Hartree type nonlinearity
where 0 < γ ⩽ 1 and d ⩾ 9. By applying the method of moving planes, we prove that nonnegative classical solutions u to (𝒫γ) are radially symmetric about some point x0 ∈ ℝd and derive the explicit form for u in the Ḣ2 critical case γ = 1. We also prove the non-existence of nontrivial nonnegative classical solutions in the subcritical cases 0 < γ < 1. As a consequence, we also derive the best constants and extremal functions in the corresponding Hardy-Littlewood-Sobolev inequalities.
$$\Delta ^2u = \left( {\displaystyle{1 \over { \vert x \vert ^8}}* \vert u \vert ^2} \right)u^\gamma ,\quad x\in {\open R}^d,$$
