The main objective in the rehabilitation of the comatose patient is the regaining of consciousness. The comatose state is widely perceived as a serious clinical prognosis. The use of prognostic indicators is of fundamental importance in planning the rehabilitation treatments that are necessary after the acute phase. There is no single prognostic factor or model of prediction that allows one to make an early-on forecast for individual patients in post-traumatic vegetative state (VS). To facilitate regaining contact with the environment for patients in a coma or VS, many authors have maintained that rehabilitation programs including multisensory stimulation are useful. In clinical practice, there are patients that do not receive any benefit from pharmacological manipulation with neurotransmitter drugs. Depauperation is maintained by the condition of hypercatabolism to which the traumatized organism is subject. Finally, a couple of potential secondary causes for the primary rehabilitation prognosis becoming progressively more negative are discussed.