Grower response from a mail survey indicated that musk thistle is a common and spreading problem in Tennessee nurseries. Poor herbicide selection and timing were reasons for the lack of control in most nurseries. At 31 wk after treatment preemergence herbicides or herbicide mixtures that gave 80% or greater musk thistle control in evaluation studies were atrazine, simazine, simazine + metolachlor (1.1 + 4.4 kg ai ha-1), oryzalin + isoxaben, or dithiopyr. Oryzalin, metolachlor, napropamide, or simazine + metolachlor (0.5 + 2.2 kg ha-1) gave 65, 35, 0 and 78% control of musk thistle, respectively. Glyphosate or SC-0224 at 1.7 and 2.2 kg ha-1 gave 89% or greater control of emerged musk thistle. Lactofen or HOE-39866 at 0.8 kg ha-1 gave less than 66% control of emerged musk thistle at 8 wk after treatment.