Intervening to alleviate parenting problems in mothers with major psychiatric disorders is recognized as a challenge to mental health providers. This chapter provides an overview of clinical services and treatments that address serious parenting problems in mothers with major mental illness. Hospitalization in the postpartum period disrupts the developing mother-infant attachment bond, and may undermine mother's confidence in her ability to care for her infant. Parenting coaching and skills training can be helpful interventions, especially for those mothers who did not experience effective role models in childhood, or those who lack knowledge about specific parenting behaviours. Parenting groups provide a mother with help in learning better parenting skills. The Parent's Clinic at the University of Illinois specializes in mothers with chronic mental illnesses. The parent-infant psychotherapy is based on the notion that parents may re-enact with their young child conflicts with their own attachment figures that remain unresolved.